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KMID : 0356720010170010047
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Journal of the Korean Society of Coloproctology
2001 Volume.17 No. 1 p.47 ~ p.52
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Clinical Significance of PCNA and nm23 Expression in Invasive Colorectal Carcinoma
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Kang Gu
Park Chul-Jae
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Abstract
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Purpose: It is known that PCNA (proliferating cell nuclear antigen) is associated with cell proliferating activity and nm23 with so called ’anti-metastatic’ activity. We tried to elucidate the relationships of PCNA labeling index and nm23
expression in carcinoma cells with survival rates of patients with invasive colorectal carcinoma.
Methods: Immunohistochemical study was performed using monoclonal antibodies for PCNA and nm23 gene products on 45 cases of paraffin-embedded tissue made of invasive colorectal cancer.
Results: Five-year survival rate was lower in the group with high PCNA labeling index than that with low one, but PCNA labeling index was not associated with the tumor stages. Expression of nm23 was not associated with survival rate, tumor stage, site, and PCNA labeling index.
Conclusion: Although PCNA labeling index was not associated with tumor stages, this study suggests that PCNA labeling index will be a good prognostic factors in invasive colorectal carcinoma.
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KEYWORD
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PCNA, nm23, Colorectal carcinoma
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